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The human dataset is still too small to answer the questions that matter most

217 This metal binding site is buried at the bottom of a solvent accessible cavity, where it facilitates the binding of small organic acids that harbor a carboxylate group in a way that is required for transcriptional regulation (Figure 18B)

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Riklan M, Kabat C, Cooper IS

17% and 8% of the men decreased or increased their dose, respectively

While the clinical significance remains unclear, women relying on oral contraceptives should be advised about potential interactions and may need to consider additional contraceptive methods or more frequent monitoring to ensure continued effectiveness