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Moreover, GA was encapsulated in stealth liposomes, which were functionalized with transferrin (Tf) to deliver the drug directly to the brain for sustained release ( In summary, the use of various formulation technologies has enabled the precise and effective application of GA across different areas, adding significant value to its clinical use

The role of iron in AMD has also been evidenced in various animal models of iron overload that mimic features of AMD [51, 52]

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats