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These findings are encouraging but must be interpreted with appropriate caution

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.McHugh D., Gil J

Large hydrophilic molecules (including most peptides) blocked unless specific transport mechanisms exist

50 l phosphate-buffered saline was used as negative and 0.01 U bovine GPX (Sigma Aldrich) as positive control, respectively

Such endpoints depend on pronounced OxS and diminished antioxidant defense systems at the molecular level (7981)

Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote syn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]