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Data analysis: ARM, MM, HM, MJL, and SG
Nat Commun 11:3369 [DOI] [PMC free article] [PubMed] [Google Scholar] 92.Liang H, Liu P, Wang Z, Xiong H, Yin C, Zhao D, Wu C, Chen L (2024) TREM2 gene induces differentiation of induced pluripotent stem cells into dopaminergic neurons and promotes neuronal repair via TGF- activation in 6-OHDA-lesioned mouse model of Parkinsons disease
The patients who received GH or IGF-1 treatment prior to the study were also excluded
Causality was established in preclinical in vivo experiments that, first, showed that down-regulating GSH levels through micro-injections of the GSH synthesis inhibitor buthionine sulfoximine in the nucleus accumbens impaired effort-based reward-incentivized performance
Another source may be the normal turn-over of beta cells
927 Transcriptional analysis indicates that the Hippo signaling pathway may be downstream of HDAC3, and overexpression of transcriptional regulator YAP or inhibition of the Hippo pathway both significantly reduce hepcidin levels
