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Systemic pharmacologic inhibition of TrxR activity in mice or humans is well tolerated 17 and, using conditional alleles to bypass embryonic lethality, it has been shown that TrxR1-null cells and tissues are robust 18,20,21

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.The glutathione system in Parkinson's disease and its progression

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De AK, Muthiyan R, Mondal S, Mahanta N, Bhattacharya D, Ponraj P, Muniswamy K, Kundu A, Kundu MS, Sunder J, et al