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Key Players in POTS Recovery Vagus Nerve A vital player in recovery is the vagus nerve, which connects the brain to every major organ and accounts for 80% of the parasympathetic nervous system

The native peptide has limited blood-brain barrier penetration, which is part of why some recent research has focused on DSIP fusion peptides combined with cell-penetrating sequences (like Tat) to improve CNS delivery

The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1

Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to bi-allelic OPLAH mutations: 20 new mutations in 14 families

For traumatic brain injury specifically, P21 addresses what is perhaps the most frustrating aspect of recovery: the loss of neural architecture