glutathione reductase activity in oxidative stress system enhancement for cardiac protection: pharmacological options against and ferroptosis Mathematical model for glutathione dynamics

Le glutathion est compos de trois acides amins essentiels : la cystine, l'acide glutamique et la glycine

Swapnil P, Meena M, Singh SK, Dhuldhaj UP, Harish, Marwal A

The reaction formula can be summarized as follows: 2 GSH GSSG + 2H + 2e (under the action of GPX or ROS) However, to prevent GSSG accumulation from disrupting the intracellular sulfhydryl balance, cells need to rapidly convert it back to GSH through an efficient reduction system

For instance, single-cell transcriptomic profiling has revealed cell-type specific ROS responses in retinal endothelial cells and Mller glia under diabetic conditions (56)

The FASEB Journal, 2019

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