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S., Alagarsamy, V., Solomon, V

Erkut, C., Gade, V

Dual Inhibition of MDM2 and XPO1 Induces Synergistic Apoptosis in Wild-type p53 Acute Myeloid Leukemia through Nuclear Accumulation of p53 and Suppression of c-Myc

These potent ROS result in oxidative damage of nucleic acids, lipids and proteins

19,84 Hepatocyte-specific SIRT1 knockout mice display liver steatosis, triglyceride accumulation, and increased de novo lipogenesis, even under standard dietary conditions, accompanied by SREBP-1c activation and impaired PGC-1/peroxisome proliferator-activated receptor alpha (PPAR) signaling

doi: 10.1021/acsbiomaterials.9b01384