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Douki et al
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Its key mechanism lies in the activation of AMP-activated protein kinase (AMPK) , a cellular energy sensor often referred to as the bodys metabolic master switch. When AMPK is activated by MOTS-c, several critical processes occur: Improved Glucose Utilization MOTS-c enhances insulin sensitivity, enabling cells to absorb and use glucose more effectively
In some rare cases, very high levels of B12 in the blood can be associated with minor side effects like mild acne, dizziness, or a temporary rash
In preclinical mouse models, MOTS-C administration prevented body weight gain of approximately 1520% in high-fat-diet cohorts compared with untreated controls (Lee et al., 2015
10.3390/antiox10030483 249 SpicuzzaL.ParisiG
