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Consistent with this overall concept is the finding that in yeast, the FMN-dependent quinone reductase Lot6 has been shown to act as a redox switch which senses oxidative stress and modulates the binding of the transcription factor Yap4 to the 20s proteasome (Sollner et al., 2009)

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doi: 10.1073/pnas.2016818118 131 HagenFLumbschHTArsic ArsenijevicVBadaliHBertoutSBillmyreRBet al

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In addition, a human study reported increased GS plasma levels in individuals with autism 47

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In coupled mitochondria, the maximum rate of ETC, measured as oxygen consumption, is only observed in the presence of ADP (Fig

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Instead, Jayawardena et al

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