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Description
Loss of retraction: Once stretched past their limit, these fibers lose their ability to bounce back
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Persistent DNA damage leads to the formation of chromatin-modifying segments known as DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS) [18]
Tanner et al., 2011)
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Our experiments here in the whole heart corroborate the single-cell studies, given that diamide decreased total glutathione to a similar extent in both treatment groups, yet the 4-ClDzp-mediated protection was associated with much lower levels of GSSG
