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186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria

10.1097/01.brs.0000209302.00820.fd

[DOI] [PubMed] [Google Scholar] 145.Okada S, York DA, Bray GA, Erlanson-Albertsson C

1 Much effort has been focused on wound care, with an emphasis on new therapeutic approaches and the development of technologies for acute and chronic wound management

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