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In addition, there is a likely analogy (see for review i.e., (Seiwerth et al., 2018)) with the attenuated fibrosis and scar formation in other tissues (i.e., the skin, muscle, tendon, and ligament) (Mikus et al., 2001

2004;14:A145

Mol Cryst Liq Cryst 580:5257 Mortensen A, Skibsted LH (1997) Importance of carotenoid structure in radical scavenging reactions

Given the negative surface charge and absence of targeting ligands, our nanocarrier is unlikely to utilize receptor or adsorptive-mediated transcytosis

Although the effects of systemically administered hydroxychloroquine have not been evaluated in any AAV gene therapy studies, it is likely that hydroxychloroquine would need to be administered in the weeks prior to AAV delivery to allow hydroxychloroquine to reach appropriate tissue concentrations within the eye

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