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We synthesize advances (20152025) across principal generatorsmitochondrial electron transport, NADPH oxidases, xanthine oxidoreductase and ER/peroxisomal oxidoreductasesto show how compartmental H 2 O 2 microgradients encode reversible cysteine signaling, while iron-rich niches pivot chemistry toward peroxynitrite, Fenton-derived OH, lipid peroxidation and regulated cell death (apoptosis, ferroptosis, parthanatos)

[DOI] [PubMed] [Google Scholar] 32.La Rubia M., Rus A., Molina F., Del Moral M

doi: 10.3389/fendo.2023.1120533 140 DanobeitiaJSChlebeckPJShokolenkoIMaXWilsonGFernandezLA

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