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Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

A genome-wide screening identifies Transmembrane 9 superfamily 3 (TM9SF3) as a critical regulator for PIP 2 translocation

doi: 10.3389/fgene.2022.1081262

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Mechanistically, p53 induces ferroptosis by directly inhibiting SLC7A11 via system Xc(-) or by upregulating recombinant spermidine/spermine N1-acetyltransferase 1 (SAT1) downstream of p53, which is involved in polyamine metabolism (23)