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doi: 10.1038/s41579-020-0438-4

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Several randomized controlled trials evaluating antioxidant supplementation in post-stroke populations have yielded negative or inconclusive results despite strong preclinical rationale

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In the case of ME/CFS, this energy strain may be a consequence of exertion-sensitive tissue hypoxia, leading to systemic patterns of metabolic adaptation and compensation (185)

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