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In particular, this variant produces an altered fixation of SP1 and PC4 transcription factors in the promoter, resulting in a decreased transcription activity (Sousa et al., 2009) and rs38841 in Japanese population patients (Thanseem et al., 2010)

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The figure is biologically attractive and genetically coherent, but no primary-prevention trial has tested whether treating healthy adults to below 0.6 g/L produces better outcomes than current practice

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