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Similarly, PDK1 overexpression in ovarian cancer suppresses IFN- secretion and impairs CD8 T-cell function through dysregulation of the PD-1/PD-L1 axis [177]

But, it doesnt necessarily mean that increased B12 levels cause weight loss

10.1091/mbc.e08-12-1250 Mol

Diversity of gut methanogens and functional enzymes associated with methane metabolism in smallholder dairy cattle

Neuroscience Letters 452, 111113.CrossRefGoogle ScholarPubMed Tufte, ER (1985)

However, these drugs, particularly in chronic doses, may actually have deleterious consequences for health and evoke negative side effects [74,76]
