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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

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Concentrations of 10-20mg/ml work well, requiring 0.05-0.3ml injection volumes that standard insulin syringes measure accurately

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