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Hypermethylation of the promoter regions of tumor suppressor genes correlates with transcriptional silencing and disease progression [375]
To address these challenges, various delivery methods have been investigated, including viral vectors, non-viral vectors, and rational design strategies such as chemical modifications, cationic liposomes, polymers, nanocarriers, and biocoupled siRNAs, aimed at enhancing stability and intracellular delivery (Liu F
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Van Der Gucht A, Zehou O, Djelbani-Ahmed S, Valeyrie-Allanore L, Ortonne N, Brugires P, et al
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Metal and metal oxides nanoparticles and nanosystems in anticancer and antiviral theragnostic agents
