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SCENIC+ analysis utilized this integrated dataset and was used to understand the transcription factor/gene regulation network that defines BWS patient hepatocytes, where we found activation of PPARA and RXRA

Core treatments, including lipid-lowering medications, particularly statins (e.g., atorvastatin) which reduce LDL-cholesterol (LDL-C) and stabilize plaque, are foundational

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Researchers often start with lower doses (e.g., 100-250 mcg/kg) and titrate upwards to establish a dose-response curve

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They also found that CCPP can promote the production of SCFAs both in vitro and in vivo to control blood glucose and blood lipid