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Keywords: Oxidative stress, Metals, ROS, Antioxidants, Signaling pathways, Aging, Toxicity Introduction Free radicals are chemical entities containing at least one unpaired electron in the outer shell which usually gives them high reactivity

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Copper was not recognized to have a role in the human body until the 19th century [2]

Dysbiosis (alterations in the makeup of commensal microorganisms or instability y in the microbiota environment) has been documented in UC individuals, and current therapies also impact the microbiome (42)

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