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Drug Tolerance with repeated use has been reported, and most likely results from down-regulation and/or internalization of alpha receptors

NO has a direct effect on processes such as proliferation and cell survival at lower concentrations

Consumption of -/-carotene and lycopene improves glucose metabolism in T2D patients [210,117], while vitamin A deficiency causes hyperglycemia and loss of pancreatic -cell mass [211]

Taurine has been shown to interact with GABA receptors and glycine receptors

The improved pre-weaning growth performance observed with nano-ZnO likely reflects source-dependent differences in zinc bioavailability and downstream metabolic signaling rather than a simple increase in total zinc supply

I/R injury is also a major concern in cerebral ischemia (stroke) and renal injury (kidney), highlighting the broad impact of ischemia-reperfusion across multiple organs