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GHK-Cu delivers copper ions that inhibit type 1 5-alpha reductase by up to 90% in laboratory studies (Sugimoto 1995)

Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene

However, this process is reversible, with the upregulation of S100A2 having the capacity to reverse the effects of TFAP2A silencing [60]
