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Novel delivery systems may improve stability, but consistent systemic exposure remains a primary challenge

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These synthesis-dependent choices directly influence drug loading capacity, pH-responsive release, organelle targeting, and cellular uptake, highlighting that therapeutic efficacy arises from deliberate surface and structural engineering, rather than from the carbon core alone

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Tirzepatide has been approved for T2D management - the mean HbA1c reduction in SURPASS programme ranged between 1.9 and 2.6% across the trials and 4069% of participants achieved 10% WL with the higher doses (10 and 15 mg), despite that there was no additional support for lifestyle intervention [16, 43]