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8 In noncirrhotic, malnourished patients receiving parenteral nutrition, deficiencies in cysteine (and other amino acids) also can occur, possibly caused by the loss of the first-pass delivery of methionine to the liver and portal blood flow

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This heightened angiogenic activity, primarily driven by VEGF and exacerbated by GSCs, is a major contributor to the aggressive nature of GB, presenting both challenges and opportunities for therapeutic interventions targeting the tumor vasculature [180]