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[DOI] [PubMed] [Google Scholar] 221.Simpson DSA, Oliver PL

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doi: 10.1016/j.jaci.2023.05.011 55 CatalnDMansillaMAFerrierASotoLOleinikaKAguillnJCet al

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Thus, Kpffer cells are main actors in the immune response against endotoxin/lipopolysaccharide (LPS) via Toll-Like Receptor type 4 (TLR4) signaling pathway leading to the production of pro-inflammatory mediators such as cytokines (TNF-, interleukin [IL]-1, IL-6), chemokines (monocyte chemotactic protein-1 [MCP-1]), ROS and profibrogenic factors (transforming growth factor [TGF]-, platelet-derived growth factor [PDGF]), which subsequently activate hepatic stellate cells for the production of extracellular matrix (Jeong&Gao, 2008) (Gao et al, 2011) (Figure 5)