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Within the flavonoid chemical group, diosmin, hesperidin and oxerutin (283, 284) are already well-established compounds in the treatment of various circulatory diseases, such as hemorrhoids, chronic venous insufficiency and others

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By binding with B (IB) protein inhibitor, NF-B induced molecular patterns related to cytokines and pathogens and stimulated cell surface receptors, including toll-like receptors (TLRs) to trigger the activation of IB kinase complex, lead to phosphorylation, ubiquitination and degradation of IB protein

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Cholesterol-enriched membranes are prone to forming larger immunological synapses, resulting in an enhanced avidity of T cell antigen receptor, extended signal transduction and enhanced T cell-mediated antitumor immunity

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