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Although erythrocytes do not have ER or mitochondria, Ca 2+ is also of high relevance to eryptosis [90]

Meisinger, C

However, mitochondrial dysfunction usually occurs during tumor growth since they have to make a lot of energy to maintain tumor growth (high metabolism)

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Either increasing or decreasing of pH value can be used for this purpose but decreasing of pH is commonly preferred
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This effect was mediated by the prevention of uncoupling protein 1 expression in brown adipose tissue and the modulation of macrophage functional polarity in white adipose tissue [54]
