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10.1053/j.gastro.2017.12.004 137 SowF
[DOI] [PubMed] [Google Scholar] 44.Kotz A.F., Lueen H.L., de Leeuw B.J., Verhoef J.C., Junginger H.E

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In the near future, their discoveries promise to make the devastating disease a thing of the past

156,157 Recent successes with such strategies have resulted in high impact therapies including agents that block the p53-MDM protein interaction and the formation of antiapoptotic complexes by the Bcl2 protein with Navitoclax and Venetoclax

The pathways converge on some downstream targets (such as mTOR) while also having distinct effects, possibly allowing for greater overall anabolic response than either pathway alone