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3), supporting our previous metabolic assays showing that PPP activity mainly supports fatty acid oxidation, the TCA cycle, and nucleotide synthesis

The US FDA approved an injectable version (brand name Ozempic) as an anti-diabetes treatment in the United States in 2017 and in the rest of the world in 2018

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The information compiled in this study is expected to support both academic research and pharmaceutical innovation, guiding the development of nextgeneration XO inhibitors with improved safety, efficacy, and pharmacokinetic profiles