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These factors include potent inflammatory regulators such as Interleukin (IL)-6, Leukemia inhibitory factor (LIF), C-X-C motif chemokine ligand (CXCL)1, CC motif chemokine ligand (CCL)5, and Colony stimulating factor (CSF) 1 [168]

They come primarily from industry-sponsored cosmetic studies rather than large, independent, placebo-controlled dermatological trials

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Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]

Despite the positive roles of microglia in response to cuprizone, a complete absence of microglia prevents cuprizone toxicity suggesting that these cells are also pathogenic during cuprizone-induced demyelination [189]

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