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EGCG as a chemopreventive agent can modulate angiogenesis and apoptosis by downregulation of various signaling pathways such as Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor Receptor (EGFR) and cell cycle regulatory proteins such as Mitogen-activated protein kinases (MAPK) (Shankar et al

Neutrophil infiltration during reperfusion adds a secondary ROS wave and proteases, creating a feed-forward loop of oxidative damage

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Ipamorelin acts as a ghrelin receptor agonist with selective growth hormone secretion, while tesamorelin is a growth hormone-releasing hormone (GHRH) analog approved for specific lipodystrophy indications