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doi: 10.3389/fphar.2025.1586655 Received 03 March 2025 Accepted 14 April 2025 Published 28 April 2025 Volume 16 - 2025 Edited by Jiu Chen, Nanjing University, China Reviewed by Maria Bayliak, Vasyl Stefanyk Precarpathian National University, Ukraine Imran Ahmd Khan, Jamia Hamdard University, India Updates Copyright 2025 Zhou and Wang

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Using 2D-DIGE analysis of bull sperm, it was shown that ALB, TIMP, spermadhesin-1, and binder of sperm proteins (BSP)-1, 3, and 5, PEBP1, and AKI in sperm and seminal plasma were more abundant in sperm from high fertility bulls, while PSMA6, ELSPbP1, CCT5, CCT8, and CLU were in greater amounts in seminal plasma and in sperm from low-fertility bulls