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increased xanthine oxidase (XO) activity, increased malondialdehyde (MDA) levels, and alterations in antioxidant status, such as low levels of reduced glutathione (GSH) and high levels of glutathione disulphide (GSSG).13,2426 So far, one recently published study has assessed mucosal proliferation, apoptosis and oxidative stress in duodenal biopsies of patients with cirrhosis and found a significantly increased intestinal lipid peroxidation (i.e

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This suggests that deletion of UCP2 may contribute to tumor initiation by creating a pro-oxidative state [148]

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In addition, inclusion of information on treatment with NAC is an important component of these types of studies

Children aged six months to two years should receive antibiotics if the diagnosis is certain and if the illness is severe