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ROCK regulates actin cytoskeleton reorganization by phosphorylating LIM kinase and cofilin, leading to increased endothelial cell gaps, elevated vascular permeability, and infiltration of inflammatory factors, thereby exacerbating endothelial damage [36]

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Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest