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Use methylcobalamin rather than cyanocobalamin since methylcobalamin doesn't require additional cellular processing

This dual pharmacology was achieved through iterative structure-activity relationship studies that balanced the competing requirements of GIP receptor affinity, GLP-1 receptor activation, and resistance to DPP-4 degradation

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van der Flier LG, Clevers H (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium

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Importantly, of the phospho-sites identified by MS, pT292 lies within the GAP-F5 fragment (residues 252-359) of ArfGAP1 that is robustly phosphorylated by LRRK2 ( Fig