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Catechins perform a dual action regarding ROS homeostasisthey act as potent antioxidants under normal conditions, and as prooxidants under pathological conditions, activating the pathways which signal cell death

Graaf CD, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, et al

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To ensure efficacy, specific administration guidelines have been established

In addition to histones, lactate also induces lactylation of snail, a transforming growth factor (TGF)- transcription factor that activates the TGF-/Smad2 signaling pathway, further promoting the EndMT [56]