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Contrary to expectation they discovered that the resistance was determined by spontaneous and heritable mutations independent of exposure to the phage which resembled a pattern of natural selection

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109,110 Strategies that target GHR signaling The most successful strategy to date for directly inhibiting GHR function has undoubtedly been peptide receptor antagonists, exemplified by the clinically used GHR antagonist pegvisomant (see below)

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It functions as a primary downstream mediator of growth hormone activity and is extensively researched for its involvement in cellular proliferation, differentiation, and anabolic signalling mechanisms

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