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Transgenic mice had increased levels of EAAT2 and reduced SNL-induced NP, and EAAT2 induction by ceftriaxone reduced SNL-induced NP in both mice, suggesting that overexpression of ET-1 suppressed NP by upregulating spinal EAAT2 expression via ET receptors [385]

Free ionic copper is toxic and tightly regulated in biological systems, but copper delivered as a peptide chelate bypasses those restrictions, allowing localized delivery to fibroblasts and keratinocytes without systemic copper overload

Selank is a synthetic peptide derived from the naturally occurring immunomodulatory peptide tuftsin

Abbreviations CMC, carboxymethylcellulose

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But anecdotes are vulnerable to placebo effects, regression to the mean, concurrent treatments, training changes, diet changes, natural healing, selective reporting and financial incentives