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Chili pepper or capsaicin is commonly believed to have adverse effects on the human intestine, particularly unsuitable for patients with gastrointestinal inflammation

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doi: 10.1111/nph.19602

Inhibitors such as aprotinin (trypsin/chymotrypsin inhibitor), amastatin, bestatin, boroleucine, and puromycin (aminopeptidase inhibitors) have been widely employed