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20 Similarly, in a study by Kawai et al of 75 patients with CCS receiving cisplatin-based chemotherapy regimens, the objective tumor response was low (23%)

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It has been suggested that hydrophobic surfaces lead to a more open conformation of CalB giving easier access to the substrate [57]

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In a further embodiment, the compound of the formula I is administered in combination with an antisense compound, eg ISIS-377131, which inhibits the production of the glucocorticoid receptor