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This pain can be caused by common changes caused by inflammation, including but not limited to tissue damage, swelling of the affected area and pressure on surrounding nerves, as well as the release of chemicals that sensitize nerve endings and alter the perception of pain

Microglia gone rogue: impacts on sychiatric disorders across the lifespan

Thalidomide attenuates colitis and is associated with the suppression of M1 macrophage polarization by targeting the transcription factor IRF5

doi: 10.1007/s13402-020-00575-9 238 LembergKMVornovJJRaisRSlusherBS

10.1136/thoraxjnl-2011-201059 52 DamesP.GleichB.FlemmerA.HajekK.SeidlN.WiekhorstF.et al (2007)

DMEM:F12 (1:1) ((+) pyruvic acid, (+) HEPES, (+) phenol red) was purchased from Thermo Fisher (Waltham, MA)