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Nrf2 and its downstream factor HO-1 exhibit both anti-ferroptotic and anti-inflammatory properties

136 These findings suggest that Cu may contribute to the pathogenesis of HD by inhibiting key enzymes involved in lactate metabolism

Lehnertz, B

Given that the cellular thiol network, including GSH, involves crosstalk between the cytosol and organelles, we selected two of the dysregulated enzymes, which had been identified by 2D electrophoresis, with important roles in mitochondrial function, i.e., Aco2 and mitochondrial creatine kinase (mtCK) (Fig

These data suggest that plants and some microbial TyrA orthologs share an evolutionarily conserved substrate specificity mechanism, and that acquisition of the key active site acidic residue was crucial in evolution of arogenate-specific TyrA a enzymes in plants and closely-related microbes

Ethics declarations Conflict of interest The authors have no potential conflicts of interest