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The authors suggest that CuHIS treatment likely enhanced copper transport via residual CTR1 activity, or perhaps permeated cells via a CTR1-independent process resulting in the observed modest clinical improvement (Batzios et al., 2022)
For instance, berberine can improve doxorubicin uptake in tumor tissues while simultaneously down-regulate the protein expression of P-gp and MRP1 in breast cancer
10.4161/oxim.2.5.9441 Oxid Med Cell Longev
Y.MeleA.FraserC
E.SchafeG
The response of mycobacterium tuberculosis to reactive oxygen and nitrogen species
