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Thus, a paradigm shift from the conventional approach of nutritional supplementation has been established

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196 Both probiotics and prebiotics can have favorable impacts on the composition of the gut microbiome, the community of microorganisms that normally reside in the digestive tract and may have benefits for systemic health

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This supports the crucial role PFO plays in the early stages of gas gangrene infection, where the ratio of bacterial cells to phagocytic cells is relatively low [5]