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(2021) 8:e2101222

Subjects with pre-existing hypertension (defined as baseline systolic BP 130 mmHg) showed significantly higher adverse event rates: 32% experienced blood pressure increases exceeding 20 mmHg, compared to 6% in normotensive controls

Take Action Check List IF YOU DEVELOP ANY OF THE FOLLOWING SIGNS OR SYMPTOMS YOU MUST VISIT YOUR GP OR DERMATOLOGIST FOR IMMEDIATE CLINICAL ASSESSMENT: Seek immediate advice from your GP or dermatologist if a new or existing skin, nail or mucosal (lips, inside the mouth and nose and genitalia) pigmented or non-pigmented spot, lump, lesion, mole or freckle: Gets bigger and/or changes in shape, particularly getting an irregular outline

Both act together and boost the effect of the disease to speed up necrosis

[DOI] [PubMed] [Google Scholar] 4.Spriet LL, Heigenhauser GJ

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