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Platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-), tumor necrosis factor-beta (TNF-), and thrombin also activate NOX in vascular smooth muscle cells (VSMC)

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3.2 Inflammation and immunity Moderate-intensity physical activity plays a significant anti-inflammatory role, contributing to the reduction of chronic inflammation markers such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and C-reactive protein (CRP) (41)