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Pharmacogenetics in the laboratory and the clinic

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Despite its key role in mitochondrial adaption, the regulation of PGC-1 is necessary for neuronal function

[82] Lateral hypothalamic orexin neurons innervate every component of the ascending reticular activating system (ARAS), which includes noradrenergic, dopaminergic, histaminergic, and serotonergic nuclei that promote wakefulness

This tiny chemical change has a big impact