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Toxicity from B12-derived cyanide has never been documented even with mega-dose supplementation

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Therefore, unlike with reduced folates where intestinal absorption is followed by direct incorporation into the liver, some of the UMFA in the portal blood likely bypasses the liver to subsequently bind to folate receptors on peripheral tissues such as the kidney (58)

Adequate levels of Vitamin B12 contribute to the efficient functioning of these immune cells
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